[髓核细胞治疗椎间盘退变的研究进展]
[Advances of nucleus pulposus cells for treating intervertebral disc degeneration].
作者信息
Wang Feng, Wang Yuntao, Wu Xiaotao
机构信息
Department of Orthopaedics, Affiliated Zhongda Hospital of Southeast University, Nanjing Jiangsu, 210009, P.R. China.
出版信息
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2009 Jul;23(7):864-7.
OBJECTIVE
To introduce the research of nucleus pulposus cells for treating intervertebral disc degeneration.
METHODS
The original articles in recent years about nucleus pulposus cells for treating intervertebral disc degeneration were extensively reviewed, and retrospective and comprehensive analysis was performed.
RESULTS
Nucleus pulposus cells are not only simply a remnant of embryonic notochordal cells, but have also an important influence on the well-being of the whole disc. The biological treatment strategies aim to regenerate the disc by either trying to improve the micro-environment within the disc or to increase the population of the nucleus pulposus, which includes transplanting mesenchymal stem cells to differentiate into nucleus-like cells in the degenerated intervertebral disc.
CONCLUSION
Nucleus pulposus cells or nucleus pulposus like cells based cell transplantation methods prove to be a promising and realistic approach for the intervertebral disc regeneration.
目的
介绍髓核细胞治疗椎间盘退变的研究。
方法
广泛回顾近年来关于髓核细胞治疗椎间盘退变的原始文章，并进行回顾性综合分析。
结果
髓核细胞不仅只是胚胎脊索细胞的残余，而且对整个椎间盘的健康有重要影响。生物治疗策略旨在通过改善椎间盘内微环境或增加髓核数量来使椎间盘再生，这包括移植间充质干细胞以在退变椎间盘中分化为类髓核细胞。
结论
基于髓核细胞或类髓核细胞的细胞移植方法被证明是椎间盘再生的一种有前景且切实可行的方法。
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