Pötter R, Naszaly A, Hemprich A, Haverkamp U, al-Dandashi C, Höver K H, Loncar I
Klinik und Poliklinik für Strahlentherapie-Radioonkologie-der Universität Münster.
Dtsch Z Mund Kiefer Gesichtschir. 1990 Jan-Feb;14(1):12-24.
In the treatment of adenoid cystic carcinomas, certain situations such as inoperable tumors, macroscopic tumor residues following surgery and recurrences occurring with the previous therapeutic strategies (surgery and/or photon radiotherapy) are afflicted with frequent local recurrences. In these situations the use of radiotherapy with fast neutrons (densely ionizing radiation with high energy transfer) results in absence of recurrences in approx. 70% of the cases, according to data in the literature. The advantage of using neutrons lies in their greater biological effect on slowly growing tumors. In the Hospital for Radiotherapy of the Münster University neutron therapy has been applied since 1986 for these indications using a DT neutron generator (14 MeV). Based on the results obtained in the treatment of 8 patients and a review of the literature, indications for, treatment planning and implementing of neutron therapy is illustrated. Particular consideration is given to CT and MRT. Neutron therapy offers an alternative to previously existing treatment methods for locally advanced adenoid cystic carcinomas or highly differentiated malignomas of the salivary glands. Its effectiveness should be verified by studies involving larger numbers of patients and longer observation periods.
在腺样囊性癌的治疗中，某些情况，如无法手术的肿瘤、手术后肉眼可见的肿瘤残留以及采用先前治疗策略（手术和/或光子放疗）后出现的复发，常伴有局部复发。根据文献数据，在这些情况下，使用快中子放疗（具有高能量传递的密集电离辐射）可使约70%的病例不再复发。使用中子的优势在于它们对生长缓慢的肿瘤具有更大的生物学效应。自1986年以来，明斯特大学放射治疗医院一直使用DT中子发生器（14 MeV）针对这些适应症应用中子治疗。基于对8例患者的治疗结果及文献综述，阐述了中子治疗的适应症、治疗计划及实施方法。尤其对CT和磁共振成像（MRT）给予了特别关注。中子治疗为局部晚期腺样囊性癌或唾液腺高分化恶性肿瘤提供了一种替代现有治疗方法的选择。其有效性应通过涉及更多患者和更长观察期的研究来验证。
