涎腺腺样囊性癌的快中子治疗结果。
Results of fast neutron therapy of adenoid cystic carcinoma of the salivary glands.
作者信息
Prott F J, Micke O, Haverkamp U, Willich N, Schüller P, Pötter R
机构信息
Department of Radiotherapy and Radiation Oncology, University of Munster, 48129 Münster, Germany.
出版信息
Anticancer Res. 2000 Sep-Oct;20(5C):3743-9.
BACKGROUND
Adenoid cystic carcinomas (ACC) seem to have a better response to fast neutron irradiation than to photon beam therapy because of the higher relative biological effectiveness of neutron radiation.
METHODS
Between 1986 and 1995, 72 patients with ACC of the salivary glands were treated in Münster with fast neutrons. The median age was 54 years. All the patients had either recurrent or macroscopic rest tumor prior to neutron therapy. The median total dose was 15.03 Gy. Median follow-up was 50 months.
RESULTS
39.1% of the patients achieved a complete remission and 48.6% a partial remission. The survival probability was 86% after one year, 73% after two years and 53% after five years. The recurrence-free survival was 83% after one year, 71% after two years and 45% after five years.
CONCLUSION
Neutron beam therapy seems to have been an effective treatment in these selected patients.
背景
由于中子辐射具有更高的相对生物学效应，腺样囊性癌（ACC）对快中子照射的反应似乎比对光子束治疗更好。
方法
1986年至1995年间，明斯特市用快中子对72例涎腺腺样囊性癌患者进行了治疗。中位年龄为54岁。所有患者在中子治疗前均有复发或肉眼可见的残留肿瘤。中位总剂量为15.03 Gy。中位随访时间为50个月。
结果
39.1%的患者实现完全缓解，48.6%的患者部分缓解。1年后生存率为86%，2年后为73%，5年后为53%。无复发生存率1年后为83%，2年后为71%，5年后为45%。
结论
中子束治疗对这些选定患者似乎是一种有效的治疗方法。
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