Gatt S, Dinur T, Abou-Rabia S, Kotler M, Fibach E
Department of Membrane Biochemistry, Hebrew University, Hadassah School of Medicine, Jerusalem, Israel.
Indian J Biochem Biophys. 1990 Dec;27(6):359-62.
Administration of pyrene-linked fatty acids and lipids to cultured cells or an enveloped (vesicular stomatitis) virus induced photosensitization which, following irradiation with a long ultra-violet light (LUV), resulted in killing of the cells and loss of the infectivity of the virus with the following specific effects. (i) LUV illumination of the pyrene-sphingomyelin administered cultured skin fibroblasts derived from normal individuals and patients with Niemann-Pick disease permitted selective killing of the latter. (ii) Similarly LUV illumination of pyrenedodecanoic acid (P12) incubates of leukemic cell lines mixed with human bone marrow cells permitted selective killing of the former. (iii) LUV illumination of P12 incubates of vesicular stomatitis virus decreased the infectivity of the virus by up to 12 logs.
将芘连接的脂肪酸和脂质施用于培养的细胞或包膜（水泡性口炎）病毒会引发光敏化，在用长紫外线（LUV）照射后，会导致细胞死亡和病毒感染性丧失，并产生以下特定效应。（i）对来自正常个体和尼曼-匹克病患者的培养皮肤成纤维细胞施用芘-鞘磷脂后进行LUV照射，可选择性杀死后者。（ii）同样，对与人类骨髓细胞混合的白血病细胞系的十二烷酸芘（P12）培养物进行LUV照射，可选择性杀死前者。（iii）对水泡性口炎病毒的P12培养物进行LUV照射，可使病毒的感染性降低多达12个对数。
