固相随机糖基化
Solid-phase random glycosylation.
作者信息
Agoston Károly, Kröger Lars, Dékány Gyula, Thiem Joachim
机构信息
Department of Chemistry, Faculty of Science, University of Hamburg, Martin-Luther-King-Platz 6, D-20146 Hamburg, Germany.
出版信息
J Comb Chem. 2009 Sep-Oct;11(5):813-9. doi: 10.1021/cc800205q.
Two different approaches were employed to study solid phase random glycosylations to obtain oligosaccharide libraries. In approach I, Wang resin esters were attached to the acceptors structures. Following their glycosylation and resin cleavage, the peracetylated components of the oligosaccharide libraries were characterized. In approach II, polymer-linked donor components could be employed and processed correspondingly. Approach I proved to be superior regarding yield and versatility of products and also allowed the formation of higher oligomers.
采用了两种不同的方法来研究固相随机糖基化反应以获得寡糖文库。在方法I中，将Wang树脂酯连接到受体结构上。在进行糖基化反应和树脂裂解后，对寡糖文库的全乙酰化组分进行了表征。在方法II中，可以使用聚合物连接的供体组分并进行相应处理。在产物的产率和通用性方面，方法I被证明更具优势，并且还能形成更高的寡聚物。
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