Netto J G, Collarile D C, Borges A F, Biancalana M L, Stefano H N
Serviços de Anatomia Patológica e Doenças Transmissíveis, Hospital do Servidor Público Estadual Francisco Morato de Oliveira.
Rev Paul Med. 1990 Sep-Oct;108(5):205-12.
The summaries of clinical data and the autopsy materials of 58 patients who died of acquired immunodeficiency syndrome were reviewed to study the spectrum of the pathologic features of this disease in a general hospital. Histologic sections of all organs were routinely obtained.
The most affected organs were the lungs and encephalo, those responsible for the immediate cause of death. There were 11 types of microorganisms and 3 types of tumors. Among the microorganisms, the most frequent was the cytomegalovirus and, among tumors, Kaposi's sarcoma. The microorganisms were frequently associated, mainly in the central nervous system. There was also an association of microorganisms with tumors. Many patients presented with suppurative inflammation. Besides these lesions, a lymphocytic depletion of lymphoid organs was observed.
The spectrum of pathologic changes in AIDS is vast, and pathologists should be aware of this fact to accurately diagnose the lesions they find. The morphologic lesions are neither unique nor specific for this syndrome, but in this clinical and immunologic setting they are characteristic. It became clear that several microorganisms and tumors sometimes can only be discovered by autopsy, which is an irrefutable proof that despite the modern technology, autopsy is unavoidable for the knowledge of the pathogeny of a disease.
回顾58例死于获得性免疫缺陷综合征患者的临床资料摘要及尸检材料，以研究综合医院中该疾病的病理特征谱。常规获取所有器官的组织切片。
受累最严重的器官是肺和脑，它们是直接死因。有11种微生物和3种肿瘤。在微生物中，最常见的是巨细胞病毒，在肿瘤中，最常见的是卡波西肉瘤。微生物常相互关联，主要在中枢神经系统。微生物也与肿瘤有关联。许多患者出现化脓性炎症。除这些病变外，还观察到淋巴器官的淋巴细胞耗竭。
艾滋病的病理变化谱很广，病理学家应意识到这一事实，以便准确诊断他们所发现的病变。形态学病变对该综合征既不具有独特性也不具有特异性，但在这种临床和免疫背景下它们具有特征性。很明显，有时只有通过尸检才能发现几种微生物和肿瘤，这无可辩驳地证明，尽管有现代技术，但对于了解疾病的病因，尸检是不可避免的。
