Amberson J B, DiCarlo E F, Metroka C E, Koizumi J H, Mouradian J A
Arch Pathol Lab Med. 1985 Apr;109(4):345-51.
We report the pathologic findings in specimens submitted for histologic and cytologic evaluation from 67 patients with the acquired immunodeficiency syndrome. A wide variety of opportunistic pathogens were identified in 41 patients. Mycobacterium avium-intracellulare evoked only a mild host response: granulomas, if present, were poorly formed. Biopsy specimens showing cytomegalovirus gastroenteritis required sections at multiple levels to demonstrate inclusions. Combined histologic and cytologic evaluation can increase the diagnostic yield in pulmonary and esophageal infections. Kaposi's sarcoma was found in biopsy specimens from 29 patients. Early lesions were often extremely subtle, yet distinct from, benign vascular proliferations in involuted lymph nodes. Malignant lymphoma was diagnosed in ten homosexual men who were suspected of having the acquired immunodeficiency syndrome. The lymphomas were characterized by B-cell origin, a diffuse pattern, frequent extranodal presentations, and an aggressive clinical course with prominent central nervous system involvement.
我们报告了67例获得性免疫缺陷综合征患者送检进行组织学和细胞学评估的标本的病理检查结果。41例患者中发现了多种机会性病原体。鸟分枝杆菌-胞内分枝杆菌引起的宿主反应轻微：若有肉芽肿形成，其结构也很不完善。显示巨细胞病毒性胃肠炎的活检标本需要多个层面的切片才能显示出包涵体。组织学和细胞学联合评估可提高肺部和食管感染的诊断率。在29例患者的活检标本中发现了卡波西肉瘤。早期病变往往极其细微，但与 involuted淋巴结中的良性血管增生不同。在10名疑似患有获得性免疫缺陷综合征的同性恋男性中诊断出恶性淋巴瘤。这些淋巴瘤的特征是B细胞起源、弥漫性模式、频繁的结外表现以及伴有明显中枢神经系统受累的侵袭性临床病程。
