Dei Tos A Paolo, Wagner Andrew J, Modena Piergiorgio, Comandone Alessandro, Leyvraz Serge
Department of Anatomic Pathology, General Hospital of Treviso, Treviso, Italy.
Semin Oncol. 2009 Aug;36(4):347-57. doi: 10.1053/j.seminoncol.2009.06.005.
Epithelioid neoplasms are generally carcinomas. As confirmation that every rule is meant to be broken, some sarcomas demonstrate epithelioid morphology, and can even express cytokeratins. These sarcomas have unique behavior, for example, a much higher rate of lymph node metastasis than other sarcomas. This group of sarcomas also presents diagnostic and therapeutic challenges to those clinicians who help patients contend with these difficult tumors. In this review, some of the major categories of epithelioid soft tissue tumors are described, with clinical data reported as available. Some of these tumors provide excellent opportunities to examine newer protein-targeted agents in investigational settings.
上皮样肿瘤通常为癌。正如每个规则都有例外一样，一些肉瘤呈现上皮样形态，甚至可表达细胞角蛋白。这些肉瘤具有独特的行为，例如，其淋巴结转移率比其他肉瘤高得多。这组肉瘤也给那些帮助患者应对这些难治性肿瘤的临床医生带来了诊断和治疗方面的挑战。在本综述中，描述了一些主要类型的上皮样软组织肿瘤，并报告了现有的临床数据。其中一些肿瘤为在研究环境中研究新型蛋白质靶向药物提供了绝佳机会。
