Yilmaz Deniz, Yüksel Deniz, Senbil Nesrin, Eminzade Sude, Kilinç Kamer, Anlar Banu, Gürer Yavuz
Department of Pediatric Neurology, Dr. Sami Ulus Children's Hospital, Ankara, Turkey.
Pediatr Neurol. 2009 Sep;41(3):179-82. doi: 10.1016/j.pediatrneurol.2009.04.016.
Oxidative damage plays a role in neurodegenerative diseases. Levels of cerebrospinal fluid nitrite and nitrate levels (oxidation products that provide an indirect estimation of nitric oxide) were investigated in relation to clinical and laboratory features in subacute sclerosing panencephalitis (n = 47) and age-matched control (n = 43) groups. Significantly decreased levels of nitrite (median, 4.91 micromol/L) and nitrate (median, 6.14 micromol/L) were found in the patients. Nitrite and nitrate levels did not correlate with clinical or laboratory findings, except for presence of myoclonus. Cerebrospinal fluid nitrite levels of subacute sclerosing panencephalitis patients without myoclonic jerks were significantly higher than in those with myoclonus (median, 15.63 vs 4.34 micromol/L, respectively). The higher levels of nitrite in these patients can be explained by short disease duration and early stages of disease. Nitrate levels in subacute sclerosing panencephalitis patients with myoclonus (median, 9.26 micromol/L) were higher than in those without myoclonus (median, 4.25 micromol/L). Microbleeding resulting in conversion of nitrite to nitrate and increased production of superoxide can be suggested as possible mechanisms underlying these findings.
氧化损伤在神经退行性疾病中起作用。研究了亚急性硬化性全脑炎患者（n = 47）和年龄匹配的对照组（n = 43）的脑脊液亚硝酸盐和硝酸盐水平（可间接估计一氧化氮的氧化产物）与临床和实验室特征的关系。发现患者的亚硝酸盐（中位数，4.91微摩尔/升）和硝酸盐（中位数，6.14微摩尔/升）水平显著降低。亚硝酸盐和硝酸盐水平与临床或实验室检查结果无关，但肌阵挛的存在除外。无肌阵挛性抽搐的亚急性硬化性全脑炎患者的脑脊液亚硝酸盐水平显著高于有肌阵挛的患者（中位数分别为15.63和4.34微摩尔/升）。这些患者较高的亚硝酸盐水平可以用疾病持续时间短和疾病早期来解释。有肌阵挛的亚急性硬化性全脑炎患者的硝酸盐水平（中位数，9.26微摩尔/升）高于无肌阵挛的患者（中位数，4.25微摩尔/升）。微出血导致亚硝酸盐转化为硝酸盐以及超氧化物产生增加可能是这些发现的潜在机制。
