Asahara H, Yokoi I, Tamada T, Kabuto H, Ogawab N, Mori A, Inoue H
Department of Orthopedic Surgery, Okayama University Medical School, Japan.
Res Commun Mol Pathol Pharmacol. 1996 Jan;91(1):77-83.
Nitric oxide is thought to mediate the cytotoxic effects of certain neurologic diseases. To investigate whether overproduction of nitric oxide may play a role in lumber spondylosis, we compared the levels of nitrite and nitrate in the cerebrospinal fluid (CSF) from patients with lumbar spondylosis with those from a control group by automated flow injection analysis. CSF levels of nitric oxide metabolites were significantly higher in patients with lumbar spondylosis compared with the control (p < 0.01). Nitric oxide may play a role in lumbar pain or nerve damage in sciatic and the CSF nitrite/nitrate may be used as a diagnostic parameter of spinal diseases.
一氧化氮被认为介导某些神经疾病的细胞毒性作用。为了研究一氧化氮的过量产生是否可能在腰椎间盘突出症中起作用，我们通过自动流动注射分析比较了腰椎间盘突出症患者脑脊液（CSF）中亚硝酸盐和硝酸盐水平与对照组的水平。腰椎间盘突出症患者的脑脊液一氧化氮代谢产物水平显著高于对照组（p < 0.01）。一氧化氮可能在腰痛或坐骨神经损伤中起作用，脑脊液亚硝酸盐/硝酸盐可作为脊柱疾病的诊断参数。
