Suppr超能文献

HIV-1疫苗在人外周血单核细胞中的分子免疫特征

Molecular immune signatures of HIV-1 vaccines in human PBMCs.

作者信息

Monaco Alessandro, Marincola Francesco M, Sabatino Marianna, Pos Zoltan, Tornesello Maria Lina, Stroncek David F, Wang Ena, Lewis George K, Buonaguro Franco M, Buonaguro Luigi

机构信息

Infectious Disease and Immunogenetics Section, Department of Transfusion Medicine, Clinical Center, National Institutes of Health Bethesda, MD, USA.

出版信息

FEBS Lett. 2009 Sep 17;583(18):3004-8. doi: 10.1016/j.febslet.2009.07.060. Epub 2009 Aug 6.

DOI:10.1016/j.febslet.2009.07.060
PMID:19665024
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3418664/
Abstract

The global transcriptional profile of peripheral blood mononuclear cells (PBMCs) stimulated with HIV candidate vaccine (virus-like particles, VLPs) has been evaluated in HIV-infected patients with low/high viral load compared to healthy volunteers. Baseline activation of chemokine production was observed in PBMC from HIV-infected patients and innate immune stimulation with HIV-VLPs was not blunted. The immune profile among HIV-infected patients was found to be qualitatively similar but quantitatively extremely variable. This diversity was independent of viral load and it might be dependent on individual immunogenetic traits or concurrent immunological status. This ex vivo screening strategy represents an efficient tool for guiding modifications/optimizations of vaccination strategies and understanding failures in individuals enrolled in clinical trials.

摘要

与健康志愿者相比，已在病毒载量低/高的HIV感染患者中评估了用HIV候选疫苗（病毒样颗粒，VLPs）刺激的外周血单个核细胞（PBMC）的全球转录谱。在HIV感染患者的PBMC中观察到趋化因子产生的基线激活，并且HIV-VLPs的先天免疫刺激并未减弱。发现HIV感染患者之间的免疫谱在质量上相似，但在数量上差异极大。这种多样性与病毒载量无关，可能取决于个体免疫遗传特征或并发免疫状态。这种体外筛选策略是指导疫苗接种策略的修改/优化以及理解参与临床试验个体失败原因的有效工具。

相似文献

1
Molecular immune signatures of HIV-1 vaccines in human PBMCs.
FEBS Lett. 2009 Sep 17;583(18):3004-8. doi: 10.1016/j.febslet.2009.07.060. Epub 2009 Aug 6.
2
Gene expression profile of peripheral blood mononuclear cells in response to HIV-VLPs stimulation.
BMC Bioinformatics. 2008 Mar 26;9 Suppl 2(Suppl 2):S5. doi: 10.1186/1471-2105-9-S2-S5.
3
Short communication: limited induction of IL-10 in PBMCs from HIV-infected subjects treated with HIV-VLPs.
AIDS Res Hum Retroviruses. 2009 Aug;25(8):819-22. doi: 10.1089/aid.2008.0304.
4
Endotoxemia is associated with altered innate and adaptive immune responses in untreated HIV-1 infected individuals.
PLoS One. 2011;6(6):e21275. doi: 10.1371/journal.pone.0021275. Epub 2011 Jun 24.
5
DC immunotherapy in HIV-1 infection induces a major blood transcriptome shift.
Vaccine. 2015 Jun 9;33(25):2922-9. doi: 10.1016/j.vaccine.2015.04.047. Epub 2015 Apr 24.
6
Activation of Latent HIV-1 T Cell Reservoirs with a Combination of Innate Immune and Epigenetic Regulators.
J Virol. 2019 Oct 15;93(21). doi: 10.1128/JVI.01194-19. Print 2019 Nov 1.
7
Systems analysis of MVA-C induced immune response reveals its significance as a vaccine candidate against HIV/AIDS of clade C.
PLoS One. 2012;7(4):e35485. doi: 10.1371/journal.pone.0035485. Epub 2012 Apr 19.
8
Gene Expression Signatures Associated With Immune and Virological Responses to Therapeutic Vaccination With Dendritic Cells in HIV-Infected Individuals.
Front Immunol. 2019 Apr 24;10:874. doi: 10.3389/fimmu.2019.00874. eCollection 2019.
9
A Novel Toll-Like Receptor 9 Agonist, MGN1703, Enhances HIV-1 Transcription and NK Cell-Mediated Inhibition of HIV-1-Infected Autologous CD4+ T Cells.
J Virol. 2016 Apr 14;90(9):4441-4453. doi: 10.1128/JVI.00222-16. Print 2016 May.
10
Spontaneous and antigen-induced chemokine production in exposed but uninfected partners of HIV type 1-infected individuals in North India.
AIDS Res Hum Retroviruses. 2007 Feb;23(2):261-8. doi: 10.1089/aid.2006.0146.

引用本文的文献

1
Systems Biology Analysis of the Radiation-Attenuated Schistosome Vaccine Reveals a Role for Growth Factors in Protection and Hemostasis Inhibition in Parasite Survival.
Front Immunol. 2021 Mar 11;12:624191. doi: 10.3389/fimmu.2021.624191. eCollection 2021.
2
Systems Biology Approach for Cancer Vaccine Development and Evaluation.
Vaccines (Basel). 2015 Jul 14;3(3):544-55. doi: 10.3390/vaccines3030544.
3
Microarray analysis of microRNA expression in peripheral blood mononuclear cells of critically ill patients with influenza A (H1N1).
BMC Infect Dis. 2013 Jun 3;13:257. doi: 10.1186/1471-2334-13-257.
4
Pattern of activation of human antigen presenting cells by genotype GII.4 norovirus virus-like particles.
J Transl Med. 2013 May 24;11:127. doi: 10.1186/1479-5876-11-127.
5
Peripheral blood RNA expression profiling in illicit methcathinone users reveals effect on immune system.
Front Genet. 2011 Aug 19;2:42. doi: 10.3389/fgene.2011.00042. eCollection 2011.
6
Systems biology applied to vaccine and immunotherapy development.
BMC Syst Biol. 2011 Sep 20;5:146. doi: 10.1186/1752-0509-5-146.
7
Immunogenomics and systems biology of vaccines.
Immunol Rev. 2011 Jan;239(1):197-208. doi: 10.1111/j.1600-065X.2010.00971.x.
8
Immune signatures in human PBMCs of idiotypic vaccine for HCV-related lymphoproliferative disorders.
J Transl Med. 2010 Feb 19;8:18. doi: 10.1186/1479-5876-8-18.

本文引用的文献

1
Th2 polarization in peripheral blood mononuclear cells from human immunodeficiency virus (HIV)-infected subjects, as activated by HIV virus-like particles.
J Virol. 2009 Jan;83(1):304-13. doi: 10.1128/JVI.01606-08. Epub 2008 Oct 22.
2
Gene expression profile of peripheral blood mononuclear cells in response to HIV-VLPs stimulation.
BMC Bioinformatics. 2008 Mar 26;9 Suppl 2(Suppl 2):S5. doi: 10.1186/1471-2105-9-S2-S5.
3
Improving defences at the portal of HIV entry: mucosal and innate immunity.
PLoS Med. 2008 Apr 1;5(4):e81. doi: 10.1371/journal.pmed.0050081.
4
Immunogenetic basis of HIV-1 infection, transmission and disease progression.
Vaccine. 2008 Jun 6;26(24):2966-80. doi: 10.1016/j.vaccine.2008.01.012. Epub 2008 Feb 4.
5
Inhibition of HIV-1 infectivity through an innate mechanism involving naturally occurring IgM anti-leukocyte autoantibodies.
J Immunol. 2008 Feb 1;180(3):1769-79. doi: 10.4049/jimmunol.180.3.1769.
6
The emerging role of innate immunity in protection against HIV-1 infection.
Vaccine. 2008 Jun 6;26(24):2997-3001. doi: 10.1016/j.vaccine.2007.11.060. Epub 2007 Dec 17.
7
Mucosal innate immunity as a determinant of HIV susceptibility.
Am J Reprod Immunol. 2008 Jan;59(1):44-54. doi: 10.1111/j.1600-0897.2007.00563.x.
8
Gene Set Expression Comparison kit for BRB-ArrayTools.
Bioinformatics. 2008 Jan 1;24(1):137-9. doi: 10.1093/bioinformatics/btm541. Epub 2007 Nov 15.
9
The challenge of viral immunity.
Immunity. 2007 Sep;27(3):363-5. doi: 10.1016/j.immuni.2007.08.011.
10
DNA-VLP prime-boost intra-nasal immunization induces cellular and humoral anti-HIV-1 systemic and mucosal immunity with cross-clade neutralizing activity.
Vaccine. 2007 Aug 10;25(32):5968-77. doi: 10.1016/j.vaccine.2007.05.052. Epub 2007 Jun 11.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验