National Food Institute, Technical University of Denmark (DTU), Søborg, Denmark.
Food Chem Toxicol. 2009 Dec;47(12):2951-62. doi: 10.1016/j.fct.2009.07.039. Epub 2009 Aug 6.
In this paper, we present a cumulative risk assessment of three anti-androgenic pesticides (vinclozolin, procymidone and prochloraz) using the relative potency factor (RPF) approach and an integrated probabilistic risk assessment (IPRA) model. RPFs for each substance were estimated for three reproductive endpoints (ano-genital distance, and weights of the seminal vesicles and the musculus levator ani/bulbocavernosus) in male rat foetuses exposed in utero. The cumulative dietary intake was estimated based on consumption data and residue data from the Netherlands. The IPRA model combines variability in both exposure and sensitivity between individuals into a distribution of individual margins of exposures (IMoEs) and IMoEs of 1 or less indicate a possible concern. The assessment did not result in IMoEs < or = 1. The endpoint 'weight of seminal vesicles' resulted in the lowest IMoEs (0.1th percentile: 198) and the fraction of individuals with IMoEs<1000 was 1.43%. For the two other endpoints, the fractions were slightly lower. Thus, cumulative dietary exposure of Dutch women to vinclozolin, procymidone and prochloraz is not likely to be of concern for the reproductive development of their male foetuses. However, other anti-androgenic substances and exposure routes should also be included in the cumulative assessment to make it more comprehensive.
本文采用相对效力因子（RPF）方法和综合概率风险评估（IPRA）模型，对三种抗雄激素农药（伏氯唑、菌核净和丙环唑）进行了累积风险评估。对雄性大鼠胎儿宫内暴露于三种生殖终点（肛门生殖器距离、精囊和提肛肌/球海绵体肌重量）的三种物质的 RPF 进行了估计。累积膳食摄入量是根据荷兰的消费数据和残留数据估算的。IPRA 模型将个体间暴露和敏感性的变异性结合在一起，形成个体暴露边际（IMoE）的分布，IMoE 值等于或小于 1 表明可能存在问题。评估结果未导致 IMoE 值<或=1。终点“精囊重量”导致最低的 IMoE 值（0.1 百分位：198），IMoE 值<1000 的个体比例为 1.43%。对于另外两个终点，该比例略低。因此，荷兰女性通过膳食累积暴露于伏氯唑、菌核净和丙环唑，不太可能对其男性胎儿的生殖发育造成影响。然而，为了使累积评估更加全面，还应包括其他具有抗雄激素作用的物质和暴露途径。
