Naumova A K, Kisselev L L
Engelhardt Institute of Molecular Biology, Academy of Sciences of the USSR, Moscow.
Biomed Sci. 1990 Mar;1(3):233-8.
The incidence of free and integrated hepatitis B virus (HBV) in various human tissues is discussed. Although hepadnavirus replication is restricted to a more or less stringent host cell range, it is clear that viral integration is not restricted to any particular organ but occurs in many tissues, including the placenta, embryo, and spermatozoa. The evidence for mother-to-infant transmission of HBV is presented. Direct transfer of HBV through the germ line cells and its implication in the development of embryonal tumours are discussed. HBV may thus possess potential oncogenicity not only for those directly infected by the virus, but also for their offspring.
本文讨论了乙肝病毒（HBV）在人体各种组织中的游离和整合发生率。虽然嗜肝DNA病毒的复制局限于或多或少严格的宿主细胞范围，但很明显，病毒整合并不局限于任何特定器官，而是发生在许多组织中，包括胎盘、胚胎和精子。文中还介绍了HBV母婴传播的证据。讨论了HBV通过生殖系细胞的直接转移及其在胚胎肿瘤发生中的意义。因此，HBV不仅可能对直接感染病毒的人具有潜在致癌性，对其后代也可能有此危害。
