Naumova A K, Sotnikova E N, Tsibinogin V V, Korenev V I, Bukhny A F
Mol Biol (Mosk). 1988 Jan-Feb;22(1):106-10.
Sera from children bearing embryonal tumors and from their parents were screened for the presence of hepatitis B virus (HBV) and its DNA by means of serology and molecular hybridization, respectively. Sera from tumor-bearing children and their parents both contain HBV or its DNA at average 5 times more frequently than the healthy donors or patients with non-oncological diseases. It is suggested that the presence of HBV or its DNA is caused not solely by infection during cure but also by vertical transmission from parents. The presence of HBV or its DNA might be treated as a risk factor increasing the development of embryonal tumors.
分别通过血清学和分子杂交技术，对患有胚胎性肿瘤的儿童及其父母的血清进行筛查，以检测乙型肝炎病毒（HBV）及其DNA的存在情况。患有肿瘤的儿童及其父母的血清中，HBV或其DNA的平均含量比健康供体或非肿瘤疾病患者高出5倍。这表明，HBV或其DNA的存在不仅是治疗期间感染所致，也可能是由父母垂直传播引起的。HBV或其DNA的存在可能被视为增加胚胎性肿瘤发生的一个风险因素。
