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一名难治性急性髓系白血病患者出现播散性镰刀菌病伴坏疽性脓皮病样病变。

Disseminated fusariosis with ecthyma gangrenosum-like lesions in a refractory acute myeloid leukemia patient.

作者信息

Mardani Masoud, Khodashahi Rozita, Lotfali Ensieh, Abolghasemi Sara, Hakemi-Vala Mojhde

机构信息

Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Department of Medical Parasitology and Mycology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

出版信息

Curr Med Mycol. 2019 Mar;5(1):27-31. doi: 10.18502/cmm.5.1.534.

DOI:10.18502/cmm.5.1.534
PMID:31049455
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6488287/
Abstract

BACKGROUND AND PURPOSE

species is an opportunistic mold that causes disseminated infections in immunocompromised patients. Given the high mortality rate of this infection, it is important to make a definite diagnosis when encountering suspected cases.

CASE REPORT

Herein, we presented a 35-year-old man diagnosed with acute myeloid leukemia with a prolonged febrile neutropenic period and ecthyma gangrenosum-like lesions, along with fungemia and disseminated fusariosis. The patient died despite receiving combination therapy, perhaps due to the nonrecovery of neutrophil.

CONCLUSION

Ecthyma gangrenosum-like lesions due to disseminated fusariosis might be easily misdiagnosed. Consequently, more attention should be paid to the cutaneous lesions in immunocompromised patients.

摘要

背景与目的

镰孢菌属是一种机会性霉菌,可在免疫功能低下的患者中引起播散性感染。鉴于这种感染的高死亡率,在遇到疑似病例时做出明确诊断很重要。

病例报告

在此,我们报告了一名35岁男性,诊断为急性髓系白血病,伴有长时间发热性中性粒细胞减少期和坏疽性脓皮病样病变,同时伴有真菌血症和播散性镰孢菌病。尽管接受了联合治疗,患者仍死亡,可能是由于中性粒细胞未恢复。

结论

播散性镰孢菌病引起的坏疽性脓皮病样病变可能容易被误诊。因此,应更加关注免疫功能低下患者的皮肤病变。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c971/6488287/e7714ffe6c20/cmm-5-027-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c971/6488287/e7714ffe6c20/cmm-5-027-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c971/6488287/e7714ffe6c20/cmm-5-027-g001.jpg

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