Mossong Joël, Opp Matthias, Gerloff Nancy, Hau Patrick, Kremer Jacques, Lackenby Angie, Gregory Vicki, Even Jos, Huberty-Krau Pierrette, Muller Claude P, Schneider François
Microbiology, National Health Laboratory, PO Box 1102, L-1011 Luxembourg, Luxembourg.
Antiviral Res. 2009 Oct;84(1):91-4. doi: 10.1016/j.antiviral.2009.08.001. Epub 2009 Aug 7.
Human cases of oseltamivir-resistant influenza A H1N1 virus emerging in 2007-2008 in Luxembourg were not associated with treatment, prophylaxis or stockpiling of oseltamivir. Following initial local seeding, oseltamivir-resistant strains spread synchronously to sensitive strains causing a similar epidemiology and clinical symptoms.
2007 - 2008年在卢森堡出现的对奥司他韦耐药的甲型H1N1流感病毒人间病例与奥司他韦的治疗、预防或储备无关。在最初的本地播散之后,对奥司他韦耐药的毒株与敏感毒株同步传播,导致相似的流行病学特征和临床症状。