Division of International Health (Public Health), Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
Influenza Other Respir Viruses. 2013 Sep;7(5):766-71. doi: 10.1111/irv.12030. Epub 2012 Nov 5.
The prevalence and timing of emergence of oseltamivir-resistant seasonal and pandemic influenza A (H1N1) viruses in Myanmar in 2008 and 2009 are described in this report. In 2008, the oseltamivir-resistant seasonal H1N1 virus was detected at a lower rate (6%) and emerged at least 2 months later when compared with neighboring countries. Similarly, the prevalence of pandemic H1N1 virus was low (3%) and the timing of emergence was late (August 2009) in Myanmar. Interestingly, we detected three isolates that were resistant to both amantadine and oseltamivir. Limited movement of people into the country is attributed to the delayed emergence of drug-resistant seasonal and pandemic A(H1N1) viruses.
本报告描述了 2008 年和 2009 年缅甸季节性和大流行性甲型流感（H1N1）病毒奥司他韦耐药株的流行率和出现时间。2008 年，与邻国相比，检测到奥司他韦耐药季节性 H1N1 病毒的比例较低（6%），且出现时间至少晚了 2 个月。同样，缅甸大流行性 H1N1 病毒的流行率较低（3%），出现时间较晚（2009 年 8 月）。有趣的是，我们检测到三株对金刚烷胺和奥司他韦均耐药的分离株。耐药的季节性和大流行性 A(H1N1)病毒出现较晚，这归因于进入该国的人员流动有限。
