Bierman E L, Albers J
Biochim Biophys Acta. 1977 Jul 20;488(1):152-60. doi: 10.1016/0005-2760(77)90133-3.
The ability of cultured human arterial smooth muscle cells to regulate low density lipoprotein (LDL) receptor activity was tested. In contrast to human skin fibroblasts incubated with lipoprotein deficient medium under identical conditions, smooth muscle cells showed significantly reduced enhancement of 125I-labeled LDL and 125I-labeled VLDL (very low density lipoprotein) binding. Smooth muscle cells also failed to suppress LDL receptor activity during incubation with either LDL or cholesterol added to the medium, while fibroblasts shoed an active regulatory response. Thus, in comparison with the brisk LDL receptor regulation characteristic of skin fibroblasts, arterial smooth muscle cells have and attenuated capacity to regulate their LDL receptor activity. These results may be relevant to the propensity of these cells to accumulate LDL and cholesterol and form "foam cells" in the arterial wall in vivo, a process associated with atherogenesis.
对培养的人动脉平滑肌细胞调节低密度脂蛋白（LDL）受体活性的能力进行了测试。与在相同条件下用缺乏脂蛋白的培养基孵育的人皮肤成纤维细胞相比，平滑肌细胞对125I标记的LDL和125I标记的极低密度脂蛋白（VLDL）结合的增强作用明显降低。在培养基中添加LDL或胆固醇孵育期间，平滑肌细胞也无法抑制LDL受体活性，而成纤维细胞则表现出活跃的调节反应。因此，与皮肤成纤维细胞活跃的LDL受体调节特性相比，动脉平滑肌细胞调节其LDL受体活性的能力减弱。这些结果可能与这些细胞在体内动脉壁中积累LDL和胆固醇并形成“泡沫细胞”的倾向有关，这一过程与动脉粥样硬化的发生有关。
