血小板衍生生长因子刺激低密度脂蛋白受体的活性。
Platelet-derived growth factor stimulates activity of low density lipoprotein receptors.
作者信息
Chait A, Ross R, Albers J J, Bierman E L
出版信息
Proc Natl Acad Sci U S A. 1980 Jul;77(7):4084-8. doi: 10.1073/pnas.77.7.4084.
Abstract
Partially purified platelet-derived growth factor stimulates low density lipoprotein binding and degradation in cultured aortic smooth muscle cells of monkeys by increasing the number of available low density lipoprotein receptors. When platelet-derived growth factor was added to quiescent cells, low density lipoprotein binding increased within 4-8 hr. Stimulation of low density lipoprotein receptor activity preceded stimulation of DNA synthesis by platelet-derived growth factor by 8-12 hr. Enhancement of endogenous cholesterol synthesis by platelet-derived growth factor preceded stimulation of low density lipoprotein receptor activity. These findings suggest that the platelet-derived growth factor can increase both the exogenous and endogenous supplies of cholesterol to the cell for its use during cell proliferation.
摘要
部分纯化的血小板衍生生长因子通过增加可用的低密度脂蛋白受体数量，刺激猴主动脉平滑肌细胞培养物中低密度脂蛋白的结合和降解。当将血小板衍生生长因子添加到静止细胞中时，低密度脂蛋白结合在4 - 8小时内增加。血小板衍生生长因子对低密度脂蛋白受体活性的刺激比其对DNA合成的刺激提前8 - 12小时。血小板衍生生长因子对内源性胆固醇合成的增强先于对低密度脂蛋白受体活性的刺激。这些发现表明，血小板衍生生长因子可以增加细胞外源性和内源性胆固醇的供应，以供细胞在增殖过程中使用。
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