Bierman E L, Albers J J, Chait A
J Gerontol. 1979 Jul;34(4):483-8. doi: 10.1093/geronj/34.4.483.
The ability of human arterial smooth muscle cells growing in tissue culture to bind, incorporate and degrade low density lipoproteins (LDL) was studied as a function of cell donor age from 5 to 71 years. LDL binding to cell surface receptors did not change with donor age. However, LDL degradation was significantly decreased in cells from older donors. These results may be relevant to the enhanced accumulation of cellular cholesterol and LDL observed in the aging human artery. Thus, impaired LDL degradation by arterial smooth muscle cells may be one of several factors involved in the accelerated development of atherosclerosis with aging.
研究了在组织培养中生长的人动脉平滑肌细胞结合、摄取和降解低密度脂蛋白（LDL）的能力，该能力是5至71岁细胞供体年龄的函数。LDL与细胞表面受体的结合不随供体年龄而变化。然而，来自老年供体的细胞中LDL降解显著减少。这些结果可能与在衰老的人类动脉中观察到的细胞胆固醇和LDL积累增加有关。因此，动脉平滑肌细胞对LDL降解的受损可能是随着年龄增长动脉粥样硬化加速发展所涉及的几个因素之一。
