Section of Obstetrics and Gynaecology and Public Health, Panhellenic Association for Continual Medical Research, Athens, Greece.
Section of Obstetrics and Gynaecology and Public Health, Panhellenic Association for Continual Medical Research, Athens, Greece.
Fertil Steril. 2010 Sep;94(4):1261-1266. doi: 10.1016/j.fertnstert.2009.06.052. Epub 2009 Aug 8.
To investigate the effect of double versus single intrauterine insemination (IUI) per treatment cycle in women with unexplained infertility.
Meta-analysis of randomized controlled trials.
MAIN OUTCOME MEASURE(S): Clinical pregnancy rates per couple.
INTERVENTION(S): Electronic searches of the Cochrane Central Trials Registry and Medline without year and language restriction through March 2009; hand searching of the abstract books of the European Society of Human Reproduction and Embryology and American Society for Reproductive Medicine annual meetings (2001-2008).
RESULT(S): Six randomized trials, involving 829 women, were included in the analysis. Fifty-four (13.6%) clinical pregnancies were recorded for treatment with double IUI and 62 (14.4%) for treatment with single IUI. There was no significant difference between the single and double IUI groups in the probability for clinical pregnancy (odds ratio, 0.92; 95% confidence interval, 0.58-1.45; P=0.715).
CONCLUSION(S): Double IUI offers no clear benefit in the overall clinical pregnancy rate in couples with unexplained infertility.
研究不明原因不孕女性每个治疗周期行双宫腔内人工授精（IUI）与单宫腔内人工授精相比的效果。
随机对照试验的荟萃分析。
每对夫妇的临床妊娠率。
电子检索 Cochrane 中心临床试验注册库和 Medline，未限制年份和语言，检索时间截至 2009 年 3 月；手工检索欧洲人类生殖和胚胎学会和美国生殖医学学会年会摘要集（2001-2008 年）。
分析纳入了 6 项随机试验，共 829 名女性。双宫腔内 IUI 治疗组有 54 例（13.6%）妊娠，单宫腔内 IUI 治疗组有 62 例（14.4%）妊娠。双宫腔内 IUI 组与单宫腔内 IUI 组的临床妊娠概率无显著差异（优势比，0.92；95%置信区间，0.58-1.45；P=0.715）。
对于不明原因不孕的夫妇，双宫腔内 IUI 在总体临床妊娠率方面无明显优势。
