Fromme Hermann, Albrecht Michael, Boehmer Sigrun, Büchner Kerstin, Mayer Richard, Liebl Bernhard, Wittsiepe Jürgen, Bolte Gabriele
Department of Environmental Health, Bavarian Health and Food Safety Authority, Veterinärstrasse 2, D-85764 Oberschleissheim, Germany.
Chemosphere. 2009 Sep;76(11):1457-63. doi: 10.1016/j.chemosphere.2009.07.010. Epub 2009 Aug 8.
The human body burden of polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and dioxin-like polychlorinated biphenyls (dl-PCBs) and the dietary intake of dl-PCB were investigated in Germany. In total, 50 adults (between 14 and 60 years old) were recruited, and duplicate diet samples were collected over seven consecutive days from each participant. Blood samples were acquired from 48 participants. Seventeen PCDD/Fs and 12 dl-PCBs (non- and mono-ortho congeners) were measured in the blood, and all dl-PCBs were measured in duplicate diet portions. Daily intake via food was calculated by multiplying the measured concentrations by the consumption data. Median (95th percentile) concentrations in the blood (expressed as WHO-TEQ) for PCDD/Fs, non-ortho PCBs and mono-ortho PCBs were 10.1 (25.0) pg g(-1) lipid, 4.2 (14.9) pg g(-1) lipid and 4.5 (14.2) pg g(-1) lipid, respectively. The contribution of mono-ortho PCBs and non-ortho PCBs to total TEQ was 25% and 24%, respectively. For each study subject, median intake levels for seven consecutive days were calculated. From these data, the median (95th percentile) daily intake via food was 0.12 (0.32) pg TEQ kg(-1)b.w. for non-ortho congeners and 0.06 (0.12) pg TEQ kg(-1)b.w. for the mono-ortho congeners. PCB 126, PCB 118 and PCB 156 accounted for about 93% of the total PCB intake. Our study indicates that dl-PCB exposure in adults consuming a normal mixed diet is quite low at present in Germany. The median and maximum daily intake contributed to 10% and 25% to the tolerable daily intake recommended for total PCDD/Fs and dl-PCBs.
在德国，对人体中多氯二苯并 - 对二噁英（PCDDs）、多氯二苯并呋喃（PCDFs）以及类二噁英多氯联苯（dl - PCBs）的负荷量和dl - PCBs的膳食摄入量进行了调查。总共招募了50名成年人（年龄在14至60岁之间），并连续七天从每位参与者那里收集两份重复的饮食样本。从48名参与者身上采集了血液样本。对血液中的17种PCDD/Fs和12种dl - PCBs（非邻位和单邻位同系物）进行了测量，并且对两份重复的饮食样本中的所有dl - PCBs都进行了测量。通过将测量浓度乘以消费数据来计算经由食物的每日摄入量。PCDD/Fs、非邻位PCBs和单邻位PCBs在血液中的中位数（第95百分位数）浓度（以WHO - TEQ表示）分别为10.1（25.0）pg g(-1)脂质、4.2（14.9）pg g(-1)脂质和4.5（14.2）pg g(-1)脂质。单邻位PCBs和非邻位PCBs对总TEQ的贡献分别为25%和24%。针对每位研究对象，计算了连续七天的中位数摄入量水平。根据这些数据，非邻位同系物经由食物的中位数（第95百分位数）每日摄入量为0.12（0.32）pg TEQ kg(-1)体重，单邻位同系物为0.06（0.12）pg TEQ kg(-1)体重。PCB 126、PCB 118和PCB 156占总PCB摄入量的约93%。我们的研究表明，目前在德国，食用正常混合饮食的成年人中dl - PCBs的暴露量相当低。中位数和最大每日摄入量分别占总PCDD/Fs和dl - PCBs推荐每日耐受摄入量的10%和25%。
