Fromme Hermann, Albrecht Michael, Appel Markus, Hilger Bettina, Völkel Wolfgang, Liebl Bernhard, Roscher Eike
Bavarian Health and Food Safety Authority, Department of Chemical Safety and Toxicology, Pfarrstrasse 3, D-80538 Munich, Germany.
Bavarian Health and Food Safety Authority, Department of Pesticides, Contaminants, Nitrosamines, Radioactivity, Dioxins, Irradiation, Veterinaerstrasse 2, D-85764 Oberschleissheim, Germany.
Int J Hyg Environ Health. 2015 Jan;218(1):41-6. doi: 10.1016/j.ijheh.2014.07.004. Epub 2014 Jul 30.
The body burden of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs), dioxin-like (dl-PCBs) and non-dioxin-like (ndl-PCBs) polychlorinated biphenyls, and polybrominated diphenyl ethers (PBDEs) was determined in blood samples from 70 subjects between 4 and 76 years old. The participants of the study were recruited in the neighborhood of a reclamation plant located in a rural area in Southern Germany. The median concentrations (95th percentiles in parentheses), expressed as WHO2005-TEQ (toxic equivalents), for PCDD/Fs and dl-PCBs were 4.5 (17.9)pgg(-1) l.w. and 2.6 (13.2)pgg(-1) l.w., respectively. The dl-PCBs contributed 40% of the total TEQ (median values), and the most abundant congener was PCB 156. Combined, the sum of the 6 non-dioxin-like PCBs had a median of 0.773μgL(-1) and a 95th percentile of 4.895μgL(-1). For the six tetra to hepta PBDE congeners, the median was 1.8ngg(-1) l.w. (95th percentile: 16.2ngg(-1) l.w.). None of our study subjects had a body burden that exceeded the biomonitoring equivalents for dioxins or PBDE congener 99 or the human biomonitoring values for ndl-PCBs. Likewise the study group did not exceed German reference values or values obtained in similar investigations. Overall, our study did not exhibit elevated internal exposures. The results also hint further decreasing tendencies for PCDD/Fs, PCBs, and PBDEs in Germany and demonstrates that people in the vicinity of a reclamation plant with no indication of an environmental contamination did not exhibit elevated internal exposures.
在70名年龄在4至76岁之间的受试者的血液样本中，测定了多氯二苯并 - 对 - 二恶英和多氯二苯并呋喃（PCDD/Fs）、二恶英类（dl - PCBs）和非二恶英类（ndl - PCBs）多氯联苯以及多溴二苯醚（PBDEs）的人体负荷。该研究的参与者是在德国南部农村地区一家回收厂附近招募的。以WHO2005 - TEQ（毒性当量）表示的PCDD/Fs和dl - PCBs的中位数浓度（括号内为第95百分位数）分别为4.5（17.9）皮克/克体重和2.6（13.2）皮克/克体重。dl - PCBs占总TEQ（中位数）的40%，最主要的同系物是PCB 156。6种非二恶英类多氯联苯的总和中位数为0.773微克/升，第95百分位数为4.895微克/升。对于六种四至七溴二苯醚同系物，中位数为1.8纳克/克体重（第95百分位数：16.2纳克/克体重）。我们的研究对象中没有一人的人体负荷超过二恶英或PBDE同系物99的生物监测当量或ndl - PCBs的人体生物监测值。同样，该研究组也未超过德国参考值或类似调查中获得的值。总体而言，我们的研究未显示内部暴露增加。结果还表明德国的PCDD/Fs、多氯联苯和多溴二苯醚有进一步下降的趋势，并表明在没有环境污染迹象的回收厂附近的人群未出现内部暴露增加的情况。
