Odriozola J M, Ramos J A, Bloch K
Biochim Biophys Acta. 1977 Aug 24;488(2):207-17. doi: 10.1016/0005-2760(77)90178-3.
Mycobacterium smegmatis extracts contain two fatty acyl synthetase systems (Brindley, D.N., Matsumura, S. and Bloch, K. (1966) Nature 224, 666-669). One is the extensively studied multienzyme complex, (molecular weight 1.39 - 10(6)) which produces shorter C16 and C18) and longer (C24 and higher) fatty acids in a bimodal pattern. The second synthetase is acyl carrier-protein (ACP) dependent and elongates the CoA derivatives of C12 and longer chains. In contrast to the type I synthetase which also extends long fatty acyl chains, the ACP-dependent system produces homologous fatty acids up to 30 carbon atoms long in approximately equal proportions. Other properties which distinguish the ACP-dependent system from the multienzyme complex include the resistance to high concentrations of palmitoyl-CoA and to low ionic strength and the lack of stimulation by mycobacterial polysaccharides. The possibility that the two fatty acid synthetases are complimentary in their function is discussed.
耻垢分枝杆菌提取物含有两种脂肪酰合成酶系统（布林德利，D.N.，松村，S.和布洛赫，K.（1966年）《自然》224，666 - 669）。一种是经过广泛研究的多酶复合物（分子量1.39 - 10⁶），它以双峰模式产生较短的C16和C18脂肪酸以及较长的（C24及更长）脂肪酸。第二种合成酶依赖于酰基载体蛋白（ACP），并使C12及更长链的辅酶A衍生物延长。与也能延长长脂肪酰链的I型合成酶不同，依赖ACP的系统以大致相等的比例产生长达30个碳原子的同系脂肪酸。将依赖ACP的系统与多酶复合物区分开来的其他特性包括对高浓度棕榈酰辅酶A和低离子强度的抗性以及不受分枝杆菌多糖的刺激。讨论了两种脂肪酸合成酶在功能上互补的可能性。
