Kurl R N, Naylor P H, Loring J M, Todd R B, Villee C A
Department of Biological Chemistry, Harvard Medical School, Boston, MA 02115.
In Vivo. 1990 Mar-Apr;4(2):89-92.
Continuous exposure to diethylstilbestrol (DES) induces renal tumors in male hamsters. The tumor formation is preceded by an increase in pituitary weight and elevation of the pituitary hormones-alpha melanocyte stimulating hormone (aMSH) and prolactin (Pr1). A decline in Pr1 (to normal levels) but not aMSH then accompanies the development of tumors and the enlargement of the intermediate lobe of the pituitary. Hypophysectomy, castration and thymectomy reduced serum levels of aMSH. DES administered for one week increased the serum levels of both hormones in normal and castrated animals, but not in hypophysectomized hamsters.
持续接触己烯雌酚（DES）会诱发雄性仓鼠的肾肿瘤。在肿瘤形成之前，垂体重量会增加，垂体激素——α-黑素细胞刺激素（αMSH）和催乳素（Pr1）会升高。随后，随着肿瘤的发展和垂体中间叶的增大，Pr1水平下降（至正常水平），而αMSH水平则不然。垂体切除、去势和胸腺切除会降低血清中αMSH的水平。给正常和去势动物连续注射一周DES会使两种激素的血清水平升高，但垂体切除的仓鼠则不会。
