Saluja P G, Hamilton J M, Thody A J, Ismail A A, Knowles J
Arch Toxicol Suppl. 1979(2):41-5. doi: 10.1007/978-3-642-67265-1_3.
One group of male Syrian hamsters was killed after various periods of diethylstilboestrol (DES) treatment, ranging from 6 to 36 weeks. All developed renal tumours by 24 weeks. DES also induced hyperplastic and neoplastic changes in the pars intermedia of the pituitary with proliferation of MSH-secreting cells and elevated serum MSH concentration. Another group of male Syrian hamsters was given DES for 36 weeks followed by cessation of hormone treatment. The animals were killed at various intervals from 12 to 36 weeks after DES withdrawal. In these animals the DES-induced renal tumours underwent regression whilst the pituitary changes persisted until the termination of the experiment. The findings suggested that the hormone MSH may be implicated in renal carcinogenesis but plays no role in the maintenance of the established tumours.
一组雄性叙利亚仓鼠在接受不同时期（6至36周）的己烯雌酚（DES）治疗后被处死。到24周时，所有仓鼠都患上了肾肿瘤。DES还诱导垂体中间部发生增生和肿瘤性变化，促黑素分泌细胞增殖，血清促黑素浓度升高。另一组雄性叙利亚仓鼠接受36周的DES治疗，然后停止激素治疗。在停止给予DES后的12至36周内，在不同时间点处死这些动物。在这些动物中，DES诱导的肾肿瘤发生消退，而垂体变化持续到实验结束。这些发现表明，激素促黑素可能与肾癌发生有关，但对已形成的肿瘤的维持没有作用。
