脑室内注射巴氯芬对大鼠食物摄入量的影响。
The effect of intracerebroventricular administration of baclofen on food intake in rats.
作者信息
Ebenezer I S
机构信息
Neuropharmacology Research Group, School of Pharmacy and Biomedical Sciences, Portsmouth Polytechnic, Hampshire, UK.
出版信息
Neuroreport. 1990 Sep;1(1):73-6. doi: 10.1097/00001756-199009000-00020.
In the present study the effects of intracerebroventricular (ICV) administration of baclofen (0.1-5.0 nmol) was investigated on food intake in non-fasted rats. Baclofen (1.0, 2.5 and 5.0 nmol) increased food consumption in a dose-related manner during the first 15-30 min after administration. The effects of baclofen (5.0 nmol) on feeding were prevented by pretreating the rats with the specific GABA-B receptor antagonist phaclofen (40 nmol, ICV). These results suggest that baclofen increases food intake in rats by an action at central GABA-B receptors.
在本研究中，研究了向非禁食大鼠脑室内注射巴氯芬（0.1 - 5.0纳摩尔）对食物摄入量的影响。巴氯芬（1.0、2.5和5.0纳摩尔）在给药后的前15 - 30分钟内以剂量相关的方式增加了食物消耗量。用特异性γ-氨基丁酸B型（GABA-B）受体拮抗剂法氯芬（40纳摩尔，脑室内注射）预处理大鼠可阻止巴氯芬（5.0纳摩尔）对进食的影响。这些结果表明，巴氯芬通过作用于中枢GABA-B受体增加大鼠的食物摄入量。
Zotero 插件