Department of Dermatology, School of Medicine, Wakayama Medical University, 811-1, Kimiidera, Wakayama, Japan.
Eur J Dermatol. 2009 Nov-Dec;19(6):594-6. doi: 10.1684/ejd.2009.0780. Epub 2009 Aug 7.
Skin ulcers in systemic lupus erythematosus (SLE) patients are non-healing or intractable, because various factors or complications, including vasculitis and immunosuppressants, impair wound healing. In the present study, we applied cultured dermal substitutes (CDSs) to 3 cases of SLE skin ulcers because various systemic or topical therapies were ineffective. CDSs are prepared by culturing human fibroblasts on two-layered spongy matrices of hyaluronic acid and atelo-collagen, and they effectively promote the healing of severe skin defects. After using CDSs in the 3 cases, healthy granulation tissues formed within 6 weeks, and skin grafts were successfully performed. These results indicate that allogeneic CDSs provide new therapeutic alternatives as topical therapies for intractable skin ulcers in SLE.
系统性红斑狼疮 (SLE) 患者的皮肤溃疡难以愈合或难以治愈，这是因为各种因素或并发症，包括血管炎和免疫抑制剂，会损害伤口愈合。在本研究中，我们对 3 例 SLE 皮肤溃疡应用了培养的真皮替代物 (CDS)，因为各种全身或局部治疗均无效。CDS 通过在透明质酸和无细胞胶原双层海绵基质上培养人成纤维细胞制备而成，可有效促进严重皮肤缺损的愈合。在这 3 例患者中应用 CDS 后，6 周内形成了健康的肉芽组织，并成功进行了皮肤移植。这些结果表明，同种异体 CDS 为治疗 SLE 难治性皮肤溃疡提供了新的治疗选择。
