Toyozawa Seiko, Yamamoto Yuki, Nishide Takeshi, Kishioka Akiko, Kanazawa Nobuo, Matsumoto Yasuhiro, Kuroyanagi Yoshimitsu, Furukawa Fukumi
Department of Dermatology, Wakayama Medical University, Wakayama, Japan.
Dermatol Online J. 2008 Nov 15;14(11):17.
Pyoderma gangrenosum (PG) is an idiopathic, inflammatory, ulcerative disease of undetermined cause. Both topical and systemic treatments of corticosteroids and cyclosporine are commonly used for the ulcers of PG, but these ulcers are often intractable despite treatment. We employed allogeneic cultured dermal substitutes (CDS) in a patient with intractable ulcers due to PG. The CDS was prepared by cultured human fibroblasts on two-layered sponges of extracellular matrix such as hyaluronic acid and atelo-collagen. In the present case, re-epithelization and healthy granulation were induced by the CDS without increasing the dosage of systemic prednisolone. Then the subsequent autologous skin graft was successfully performed. This indicates that CDS is one of the useful tools for the treatment of intractable ulcers in patients with PG.
坏疽性脓皮病（PG）是一种病因不明的特发性、炎症性溃疡性疾病。局部和全身性使用皮质类固醇及环孢素常用于治疗PG溃疡，但尽管进行了治疗，这些溃疡往往难以治愈。我们对一名因PG导致顽固性溃疡的患者使用了同种异体培养真皮替代物（CDS）。CDS是通过在两层由透明质酸和脱细胞胶原蛋白等细胞外基质构成的海绵上培养人成纤维细胞制备而成。在本病例中，CDS诱导了再上皮化和健康肉芽组织形成，且未增加全身性泼尼松龙的剂量。随后成功进行了自体皮肤移植。这表明CDS是治疗PG患者顽固性溃疡的有效工具之一。
