Department of Laboratory Medicine, Changzhou Cancer Hospital, Suzhou University, Changzhou 213001, China.
Hepatobiliary Pancreat Dis Int. 2009 Aug;8(4):397-401.
Based on differences in the virus nucleotide sequence, hepatitis B virus (HBV) genotypes are presently divided into genotypes A-H. The geographic distributions of HBV genotypes differ in countries and regions. To determine the general characteristics of their distributions in the mainland of China, we reviewed articles on HBV genotypes published in China.
The Wanfang Database and the CNKI Database were searched for original articles involving HBV in China, and then the data from the articles were classified according to genotype and latitude and analyzed using SPSS 11.0.
The main HBV genotypes were C, B and BC, and their rates were 50.99%, 35.58%, 6.07%, respectively; other genotypes were rare. There was a negative correlation between latitude and the rate of genotype B (r=-0.782, P<0.01), while a positive correlation existed between latitude and the rate of genotype C (r=0.646, P<0.01). No correlation was observed between latitude and the rates of other genotypes (r=0.294, P>0.05).
In China, HBV genotype C predominates, followed by genotype C and mixed genotype BC; genotypes A, D and others are rare. With an increasing latitude, the distribution of genotype B decreases gradually, while that of genotype C tends to increase. The other genotypes do not show any changes.
根据病毒核苷酸序列的差异，乙型肝炎病毒（HBV）基因型目前分为 A-H 型。HBV 基因型在不同国家和地区的地理分布存在差异。为了确定其在中国大陆的分布特点，我们对中国发表的有关 HBV 基因型的文章进行了综述。
在万方数据库和中国知网数据库中检索中国 HBV 的原始文章，并根据基因型和纬度对文章中的数据进行分类，使用 SPSS 11.0 进行分析。
主要的 HBV 基因型为 C、B 和 BC，其出现率分别为 50.99%、35.58%、6.07%；其他基因型较为少见。HBV 基因型 B 的出现率与纬度呈负相关（r=-0.782，P<0.01），而 HBV 基因型 C 的出现率与纬度呈正相关（r=0.646，P<0.01）。其他基因型与纬度之间不存在相关性（r=0.294，P>0.05）。
在中国，HBV 基因型 C 占优势，其次是基因型 C 和混合基因型 BC；基因型 A、D 和其他基因型较为少见。随着纬度的增加，基因型 B 的分布逐渐减少，而基因型 C 的分布则呈增加趋势。其他基因型没有变化。
