中国云南10个民族无症状人群的乙型肝炎病毒感染与基因型
Hepatitis B virus infection and genotype in asymptomatic people from 10 ethnic groups in Yunnan, China.
作者信息
Shen Yuan-Ying, Hou Wei, Yang Zhan-Qiu, Xiao Wen
机构信息
Yuan-Ying Shen, Wei Hou, Zhan-Qiu Yang, Institute of Virology, Medical School of Wuhan University, Wuhan 430071, Hubei Province, China.
出版信息
World J Gastroenterol. 2015 Nov 28;21(44):12586-92. doi: 10.3748/wjg.v21.i44.12586.
AIM
To evaluate the infection and genotype distribution of hepatitis B virus (HBV) in ethnic groups in Yunnan, China.
METHODS
Two thousand five hundred and eighty-four asymptomatic local people from 10 ethnic groups were investigated in Yunnan, China. Infection and genotype distribution were evaluated by serological and genetic methods. Genotyping was verified by sequencing. Ethnic genotype distribution was compared by proportion test.
RESULTS
Four types of infection model based on HBV serum markers were identified, and the average HBV infection rate was 5.7% in those asymptomatic local people. The genotype prevalence was 59.6% for B, 21.1% for C and 19.3% BC; subgenotypes Ba, Cs and Ce were identified in this study. Hepatitis B surface antigen-positive rate and the proportion of genotype B were significantly lower in ethnic groups with a northern origin compared to those with a southern origin (50% vs 73.9%, P = 0.037; 4.2% vs 10.5%, P = 0.000).
CONCLUSION
Genotype B is dominant and genotype BC has high occurrence in asymptomatic local ethnic groups in Yunnan. HBV infection status and genotype distribution may associate with ethnic origin.
目的
评估中国云南少数民族人群中乙型肝炎病毒（HBV）的感染情况及基因型分布。
方法
对中国云南10个少数民族的2584名无症状当地人进行调查。采用血清学和基因方法评估感染情况及基因型分布。通过测序验证基因分型。采用比例检验比较民族基因型分布。
结果
基于HBV血清学标志物确定了4种感染模式，这些无症状当地人的平均HBV感染率为5.7%。基因型B的流行率为59.6%，基因型C为21.1%，基因型BC为19.3%；本研究中鉴定出了B亚型、C亚型和C基因型e亚型。与南方起源的民族相比，北方起源的民族中乙型肝炎表面抗原阳性率和基因型B的比例显著较低（50%对73.9%，P = 0.037；4.2%对10.5%，P = 0.000）。
结论
基因型B在云南无症状当地少数民族人群中占主导地位，基因型BC的发生率较高。HBV感染状况和基因型分布可能与民族起源有关。
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