Lin T J, Liu G T, Li X J, Zhao B L, Xin W J
Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing.
Zhongguo Yao Li Xue Bao. 1990 Nov;11(6):534-9.
It was reported that Schisanhenol (Sal) isolated from Schisandrae Rubriflora inhibited lipid peroxidation induced by ferrous-cysteine and NADPH-ascorbic acid. In this studies the oxygen radical scavenging activity of Sal was detected by electron spin resonance (ESR) and spin trapping. Sal was shown to scavenge oxygen radicals produced by human neutrophils (Neu) stimulated by tetradecanoylphorbol acetate (TDPA). But no effect of Sal was seen on oxygen consumption measured by spin label oximetry in Neu during respiratory burst. In Fenton reaction system, the inhibitory rate of hydroxyl radical by Sal was 34.4%. In xanthine-xanthine oxidase and uv-irradiation of riboflavin systems, Sal scavenged superoxide anion radical by 26.1% and 21.9%, respectively. In all these systems the action of Sal was more potent than that of vitamin E. It may be concluded that Sal possesses a free radical-scavenging activity.
据报道，从红花五味子中分离得到的五味子醇（Sal）可抑制由半胱氨酸亚铁和NADPH-抗坏血酸诱导的脂质过氧化。在本研究中，通过电子自旋共振（ESR）和自旋捕获法检测了Sal的氧自由基清除活性。结果表明，Sal可清除由十四酰佛波醇乙酸酯（TDPA）刺激的人中性粒细胞（Neu）产生的氧自由基。但在呼吸爆发期间，用自旋标记血氧测定法测量，Sal对Neu中的耗氧量没有影响。在芬顿反应体系中，Sal对羟自由基的抑制率为34.4%。在黄嘌呤-黄嘌呤氧化酶体系和核黄素紫外线照射体系中，Sal对超氧阴离子自由基的清除率分别为26.1%和21.9%。在所有这些体系中，Sal的作用比维生素E更强。可以得出结论，Sal具有自由基清除活性。
