Lin T, Liu G, Pan Y
Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing.
Biomed Environ Sci. 1992 Mar;5(1):57-64.
Schisanhenol (SAL) had been shown to have potent antioxidant activities. The protective effects of SAL against oxygen radical induced mitochondrial injuries of rat heart and liver were investigated in the present study. The ferrous-cysteine induced mitochondrial lipid peroxidation was significantly inhibited by SAL, while the loss of ATPase activity induced by the lipid peroxidation was prevented. The rigidification of mitochondrial membrane, as well as swelling, lysis and disintegration of the mitochondria induced by ferrous-cysteine were all significantly inhibited by SAL. These results further confirm that SAL possesses antioxidant activity.
五味子醇（SAL）已被证明具有强大的抗氧化活性。本研究考察了SAL对氧自由基诱导的大鼠心脏和肝脏线粒体损伤的保护作用。SAL显著抑制了亚铁-半胱氨酸诱导的线粒体脂质过氧化，同时防止了脂质过氧化诱导的ATP酶活性丧失。亚铁-半胱氨酸诱导的线粒体膜僵化以及线粒体的肿胀、裂解和崩解均被SAL显著抑制。这些结果进一步证实SAL具有抗氧化活性。
