Rybakowski J, Ziółkowski M, Filek W, Modrzejewski B
Katedry i Kliniki Psychiatrii AM w Bydgoszczy.
Psychiatr Pol. 1990 Jul-Aug;24(4):20-4.
The effect of disulfiram ("Anticol") treatment lasting from 7 to 12 months of 57 alcohol dependent out-patients was evaluated. The satisfactory results (i.e. patients remained abstinent and took the medication regularly) were observed in 30 patients. Those patients did not differ from others in regard to age, length of alcohol abuse, the severity of dependence, the genetic encumbrance , the features of alexithymia , and the membership of AA-clubs. The percentage of patients with positive treatment results was significantly higher among subjects with high self-motivation to treatment, among married subjects, and among those professionally active. The findings are similar to the recent American results where about a half of alcoholics showed positive effects of disulfiram treatment, especially those with high motivation to the treatment and with the stabile social position.
对57名酒精依赖门诊患者进行了为期7至12个月的双硫仑（“戒酒硫”）治疗效果评估。在30名患者中观察到了满意的结果（即患者保持戒酒且定期服药）。这些患者在年龄、酗酒时间、依赖严重程度、遗传负担、述情障碍特征以及戒酒互助会成员身份方面与其他患者没有差异。在治疗自我动机高的受试者、已婚受试者以及职业活跃的受试者中，治疗结果为阳性的患者百分比显著更高。这些发现与美国最近的结果相似，在美国约有一半的酗酒者双硫仑治疗显示出积极效果，尤其是那些治疗动机高且社会地位稳定的人。
