Kawamura M, Sudo T, Miyamoto M, Yasuda C, Bessho H, Fukunishi K, Uchida T, Tsubakimoto R, Kuyama T
Second Department of Surgery, Kinki University School of Medicine, Osaka-Sayama, Japan.
Nihon Geka Hokan. 1990 Nov 1;59(6):454-7.
Recently, we experienced a case of obstructive jaundice caused by a carcinoma of the head of the pancreas which could not be relieved by reduction surgery. The operation performed was a cholecystectomy and supraduodenal choledochotomy with T-tube insertion. Glucagon and insulin were, therefore, administered with the aim towards the recovery of the liver function to be induced by the enhancement of the liver regeneration. The treatment, however, was not effective. Then, dibutyryl cyclic AMP was administered to the case by intravenous drip infusions at the rate of 5 micrograms/kg/min. Thereafter, the value of serum total bilirubin was reduced remarkably. A prolonged and intense obstructive jaundice is generally accompanied by damage to the liver function, and the condition carries a high risk of postoperative complication. In this paper, the effectiveness of dibutyryl cyclic AMP on liver cell damage caused by prolonged obstructive jaundice are reported.
最近，我们遇到一例由胰头癌引起的梗阻性黄疸病例，减压手术无法缓解该症状。所施行的手术为胆囊切除术和十二指肠上段胆总管切开术并插入T形管。因此，给予了胰高血糖素和胰岛素，目的是通过增强肝再生来促进肝功能恢复。然而，该治疗方法无效。随后，以5微克/千克/分钟的速率通过静脉滴注向该病例施用二丁酰环磷腺苷。此后，血清总胆红素值显著降低。长期严重的梗阻性黄疸通常伴有肝功能损害，且该病症术后并发症风险很高。本文报道了二丁酰环磷腺苷对长期梗阻性黄疸所致肝细胞损伤的疗效。
