在病毒学失败期间对1型人类免疫缺陷病毒的拉替拉韦敏感性和整合酶复制能力的纵向分析。
Longitudinal analysis of raltegravir susceptibility and integrase replication capacity of human immunodeficiency virus type 1 during virologic failure.
作者信息
Fransen Signe, Karmochkine Marina, Huang Wei, Weiss Laurence, Petropoulos Christos J, Charpentier Charlotte
机构信息
Monogram Biosciences, South San Francisco, California, USA.
出版信息
Antimicrob Agents Chemother. 2009 Oct;53(10):4522-4. doi: 10.1128/AAC.00651-09. Epub 2009 Aug 10.
Abstract
We characterized the raltegravir (RAL) susceptibility and the integrase (IN)-mediated replication capacity (RC) of RAL-resistant human immunodeficiency virus type 1 from two patients experiencing virologic failure during continuous RAL salvage therapy. The following two distinct outcomes were observed: (i) the selective outgrowth of virus with high-level RAL resistance and high IN-mediated RC leading to significant viral load rebound and (ii) the selection of virus with a slight reduction in RAL susceptibility and low IN-mediated RC resulting in sustained low-level viremia.
摘要
我们对两名在持续的雷特格韦挽救治疗期间出现病毒学失败的患者的1型人类免疫缺陷病毒的雷特格韦（RAL）敏感性和整合酶（IN）介导的复制能力（RC）进行了表征。观察到以下两种不同的结果：（i）具有高水平RAL耐药性和高IN介导的RC的病毒选择性生长，导致病毒载量显著反弹；（ii）选择了RAL敏感性略有降低且IN介导的RC较低的病毒，导致持续的低水平病毒血症。
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2
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Antimicrob Agents Chemother. 2000 Apr;44(4):920-8. doi: 10.1128/AAC.44.4.920-928.2000.
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