Weis Ezekiel, Rootman Jack, Joly Thomas J, Berean Kenneth W, Al-Katan Hind M, Pasternak Sylvia, Bonavolontà Giulio, Strianese Diego, Saeed Peerooz, Feldman Kenneth A, Vangveeravong Sumalee, Lapointe Jocelyne S, White Valerie A
Department of Ophthalmology, University of Alberta, Edmonton, Alberta, Canada.
Arch Ophthalmol. 2009 Aug;127(8):1016-28. doi: 10.1001/archophthalmol.2009.209.
To apply the updated epithelial salivary gland classification scheme to a large cohort of lacrimal gland tumors so as to provide an updated lacrimal gland tumor classification scheme.
A retrospective multicenter cohort study of 118 cases of epithelial neoplasia was undertaken. Main outcome measures included pathologic analysis, subtyping, and survival.
Of 118 cases, 17 (14%) were reclassified using the proposed expanded classification scheme based on the current World Health Organization classification of salivary gland tumors. The most frequent neoplasms were pleomorphic adenoma and adenoid cystic carcinoma, of which we highlight more unusual histologic features. Three tumors were found to be unclassifiable with the updated scheme, with 2 having histologically malignant features. Deficiencies and variations in pathologic assessment were noted. Variation in the histologic findings of pleomorphic adenoma and assessment of the extent of invasion of carcinoma ex pleomorphic adenoma were highlighted.
The use of the more histologically diverse classification of salivary gland tumors can be successfully applied to the epithelial lacrimal gland neoplasms. This expanded classification system led to reclassifying 14% of cases. Currently, there are no consistent pathologic standards for processing and evaluating these lesions.
将更新后的涎腺上皮性肿瘤分类方案应用于一大组泪腺肿瘤，以提供一个更新的泪腺肿瘤分类方案。
对118例上皮性肿瘤进行回顾性多中心队列研究。主要观察指标包括病理分析、亚型分类和生存率。
在118例病例中，根据世界卫生组织目前的涎腺肿瘤分类，采用提议的扩展分类方案对17例（14%）进行了重新分类。最常见的肿瘤是多形性腺瘤和腺样囊性癌，我们重点介绍了其中更不寻常的组织学特征。发现有3例肿瘤无法用更新后的方案分类，其中2例具有组织学恶性特征。注意到病理评估存在不足和差异。重点介绍了多形性腺瘤组织学表现的差异以及多形性腺瘤癌变浸润范围的评估。
涎腺肿瘤更具组织学多样性的分类可成功应用于泪腺上皮性肿瘤。这种扩展的分类系统导致14%的病例被重新分类。目前，处理和评估这些病变尚无一致的病理标准。
