Bagheri Abbas, Ashtar-Nakhaie Parisa, Aletaha Maryam, Kheiri Bahareh, Veisi Amirreza
Ocular Tissue Engineering Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Ophthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
J Ophthalmic Vis Res. 2023 Apr 19;18(2):202-211. doi: 10.18502/jovr.v18i2.13187. eCollection 2023 Apr-Jun.
In this study, we describe different orbital space-occupying lesions (SOLs) from a referral center in Iran.
In this retrospective case series, all records of "orbital tumors" with a definite histopathologic diagnosis at a referral center in Iran were reviewed from April 2008 to May 2020.
A total of 375 orbital SOLs were included. The study population consisted of 212 (56.5%) female and 163 (43.5%) male subjects with overall mean age of 31.09 21.80 years. The most common clinical presentation was proptosis and the superotemporal quadrant was the most frequent site of involvement. Extraconal lesions (276 cases, 73.6%) outnumbered intraconal lesions (99 cases 26.4%). The great majority of SOLs (344, 91.7%) were primary, while 24 (6.4%) were secondary and 7 (1.9%) were metastatic. Benign lesions (309, 82.4%) were much more common than malignant SOLs (66, 17.6%). Overall, dermoid cysts and malignant lymphoma were the most prevalent benign and malignant orbital SOLs, respectively. The malignant to benign lesion ratio was 0.46 in children (18 years), 0.81 in middle-aged subjects (19-59 years), and 5.9 in older (60 years) cases. The most common type of malignancy was rhabdomyosarcoma in children, lymphoma in middle-aged subjects, and invasive basal cell carcinoma in older age group.
Over the 12-year study period, benign, primary, extraconal orbital SOLs were more frequent than malignant, secondary, and intraconal lesions. The ratio of malignant lesions increased with age in this cohort of patients.
在本研究中，我们描述了来自伊朗一家转诊中心的不同眼眶占位性病变（SOLs）。
在这个回顾性病例系列中，对2008年4月至2020年5月期间伊朗一家转诊中心所有有明确组织病理学诊断的“眼眶肿瘤”记录进行了回顾。
共纳入375例眼眶SOLs。研究人群包括212名（56.5%）女性和163名（43.5%）男性受试者，总体平均年龄为31.09±21.80岁。最常见的临床表现是眼球突出，颞上象限是最常受累的部位。眶锥外病变（276例，73.6%）多于眶锥内病变（99例，26.4%）。绝大多数SOLs（344例，91.7%）是原发性的，而24例（6.4%）是继发性的，7例（1.9%）是转移性的。良性病变（309例，82.4%）比恶性SOLs（66例，17.6%）更为常见。总体而言，皮样囊肿和恶性淋巴瘤分别是最常见的良性和恶性眼眶SOLs。儿童（18岁）的恶性与良性病变比例为0.46，中年受试者（19 - 59岁）为0.81，老年（60岁）病例为5.9。最常见的恶性肿瘤类型在儿童中是横纹肌肉瘤，中年受试者中是淋巴瘤，老年组中是浸润性基底细胞癌。
在为期12年的研究期间，良性、原发性、眶锥外眼眶SOLs比恶性、继发性和眶锥内病变更常见。在这组患者中，恶性病变的比例随年龄增加。
