2型糖尿病的病理生理缺陷。胰岛素作用异常和胰岛素分泌受损。

The pathophysiologic defects of type 2 diabetes. Abnormal insulin action and impaired insulin secretion.

作者信息

Kahn S E

机构信息

Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, Veterans Affairs Medical Center, Seattle, WA 98108, USA.

出版信息

Postgrad Med. 2000 May 15;107(6 Suppl Key):11-5. doi: 10.3810/pgm.5.15.2000.suppl4.22.

DOI:10.3810/pgm.5.15.2000.suppl4.22

PMID:19667505

Abstract

Normal glucose metabolism is dependent on tight interplay among the pancreas, the liver, muscle, and adipose tissue. If this interplay is disturbed by decreased insulin secretion or decreased insulin effectiveness, glucose intolerance and type 2 diabetes ensue. Therapeutic approaches currently available and those under development target the pathophysiologic defects of type 2 diabetes, and treatment must be selected with this in mind, a major goal being to ensure adequate availability of insulin to the tissues.

摘要

正常的葡萄糖代谢依赖于胰腺、肝脏、肌肉和脂肪组织之间紧密的相互作用。如果这种相互作用因胰岛素分泌减少或胰岛素有效性降低而受到干扰，就会出现葡萄糖耐量异常和2型糖尿病。目前可用的治疗方法以及正在研发的方法都针对2型糖尿病的病理生理缺陷，治疗必须以此为依据进行选择，一个主要目标是确保胰岛素能充分供应到各组织。