Jones Peter H
Baylor College of Medicine, Houston, TX 77030, USA.
Postgrad Med. 2002 Oct;112(4 Suppl):23-30. doi: 10.3810/pgm.10.2002.suppl20.108.
The publication of new guidelines from the National Cholesterol Education Program poses new challenges for clinicians in terms of assessing risk and determining treatment strategies for individual patients. It is clear from accumulated epidemiologic data that lowering low-density lipoprotein cholesterol is a key element in the quest for cardiovascular health. In the past, choices for pharmacotherapeutic intervention were limited by issues of tolerance and, therefore, patient compliance. Fortunately, the statin class of drugs offer lipid lowering with both good safety and tolerability.
美国国家胆固醇教育计划发布的新指南,在评估个体患者风险及确定治疗策略方面给临床医生带来了新挑战。从积累的流行病学数据可以清楚地看出,降低低密度脂蛋白胆固醇是追求心血管健康的关键因素。过去,药物治疗干预的选择受到耐受性问题的限制,进而影响患者的依从性。幸运的是,他汀类药物在降脂的同时具有良好的安全性和耐受性。