Deedwania Prakash C
Cardiology Division, Veteran Affairs Medical Center, Fresno, CA 93703, USA.
Postgrad Med. 2002 Dec;112(6 Suppl Heart):21-7. doi: 10.3810/pgm.12.2002.suppl24.127.
Heart failure is a significant problem among the elderly. Although many nonpharmacologic interventions, such as dietary sodium restriction, and drug therapy with digoxin and angiotensin-converting enzymes are considered to be the standard of care, ss-blockers have recently been shown to improve survival and reduce morbidity when added to the standard regimen. Although studies have demonstrated a significant benefit of ss-blockers, the drugs remain underutilized, partly from concerns about tolerability. Adapting a "start low, go slow" approach and titrating dosage upward can lessen tolerability issues and improve usage among the elderly.
心力衰竭在老年人中是一个重大问题。尽管许多非药物干预措施，如限制饮食中的钠摄入，以及使用地高辛和血管紧张素转换酶进行药物治疗被视为标准治疗方法，但最近研究表明，在标准治疗方案中添加β受体阻滞剂可提高生存率并降低发病率。尽管研究已证明β受体阻滞剂有显著益处，但这些药物的使用仍未得到充分利用，部分原因是对耐受性的担忧。采用“起始剂量低，递增速度慢”的方法并逐步增加剂量可以减少耐受性问题，并提高老年人中的使用率。
