Prisant L Michael
Hypertension and Clinical Pharmacology, Unit, BI-5084, 1120 Fifteenth St, Medical College of Georgia, Augusta, GA 39012-3105, USA.
Postgrad Med. 2002 Dec;112(6 Suppl Heart):34-41. doi: 10.3810/pgm.12.2002.suppl24.129.
The prevalence of hypertension increases with age. With aging, many physiologic changes must be considered with treatment. Concerns remain about the appropriateness of beta-blocker therapy in the elderly, even though many of these are unsubstantiated, and evidence exists to support beta-blocker use. A literature search reveals that beta-blockers and nonpharmacologic interventions are effective in the elderly. Although no well-designed, long-term, large-scale, clinical trials exist that assess outcomes for beta-blockers as monotherapy for treating hypertensive elderly patients, this fact should not deter their use in combination therapy, especially for those with comorbid diseases such as angina, myocardial infarction, and heart failure.
高血压的患病率随年龄增长而增加。随着年龄的增长，治疗时必须考虑许多生理变化。尽管其中许多担忧没有事实依据，但对于老年患者使用β受体阻滞剂治疗的适宜性仍存在担忧，不过也有证据支持使用β受体阻滞剂。文献检索表明，β受体阻滞剂和非药物干预措施对老年人有效。虽然目前尚无精心设计、长期、大规模的临床试验来评估β受体阻滞剂作为单一疗法治疗老年高血压患者的疗效，但这一事实不应妨碍其在联合治疗中的使用，尤其是对于患有心绞痛、心肌梗死和心力衰竭等合并症的患者。
