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Regulation of cytotoxic T lymphocyte triggering by PIR-B on dendritic cells.树突状细胞上的PIR-B对细胞毒性T淋巴细胞触发的调节作用。
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2
Blocking indoleamine dioxygenase activity early after rat liver transplantation prevents long-term survival but does not cause acute rejection.在大鼠肝移植后早期阻断吲哚胺双加氧酶活性可阻止长期存活，但不会引起急性排斥反应。
Transplantation. 2008 May 15;85(9):1357-61. doi: 10.1097/TP.0b013e31816fc27f.
3
Induction of IRAK-M is associated with lipopolysaccharide tolerance in a human endotoxemia model.在人类内毒素血症模型中，IRAK-M的诱导与脂多糖耐受性相关。
J Immunol. 2007 Nov 15;179(10):7110-20. doi: 10.4049/jimmunol.179.10.7110.
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Gut-derived commensal bacterial products inhibit liver dendritic cell maturation by stimulating hepatic interleukin-6/signal transducer and activator of transcription 3 activity.肠道共生细菌产物通过刺激肝脏白细胞介素-6/信号转导和转录激活因子3活性来抑制肝脏树突状细胞成熟。
Hepatology. 2007 Dec;46(6):1946-59. doi: 10.1002/hep.21906.
5
Critical negative regulation of type 1 T cell immunity and immunopathology by signaling adaptor DAP12 during intracellular infection.细胞内感染期间，信号衔接蛋白DAP12对1型T细胞免疫和免疫病理学的关键负调控。
J Immunol. 2007 Sep 15;179(6):4015-26. doi: 10.4049/jimmunol.179.6.4015.
6
TGF-beta signaling: a tale of two responses.转化生长因子-β信号传导：两种反应的故事。
J Cell Biochem. 2007 Oct 15;102(3):593-608. doi: 10.1002/jcb.21501.
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Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenase.来自小鼠肿瘤引流淋巴结的浆细胞样树突状细胞通过吲哚胺2,3-双加氧酶直接激活成熟调节性T细胞。
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8
Immunological role of indoleamine 2,3-dioxygenase in rat liver allograft rejection and tolerance.吲哚胺2,3-双加氧酶在大鼠肝脏同种异体移植排斥反应和耐受中的免疫作用
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9
Tolerogenic dendritic cells and the quest for transplant tolerance.耐受性树突状细胞与移植耐受的探索
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STAT1 expression in dendritic cells, but not T cells, is required for immunity to Leishmania major.对硕大利什曼原虫产生免疫，树突状细胞而非T细胞中的信号转导和转录激活因子1（STAT1）表达是必需的。
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肝树突状细胞功能的分子调控及其与肝移植结果的关系。

Molecular regulation of hepatic dendritic cell function and its relation to liver transplant outcome.

机构信息

Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.

出版信息

Transplantation. 2009 Aug 15;88(3 Suppl):S40-4. doi: 10.1097/TP.0b013e3181af7c0d.

DOI:10.1097/TP.0b013e3181af7c0d
PMID:19667960
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2788312/
Abstract

Studies on liver interstitial dendritic cells (DC) indicate that the maturation and function of these important antigen-presenting cells may be suppressed by continual exposure to microbial products from the gut, in particular, bacterial lipopolysaccharide. New evidence is emerging for a role of specific intracellular regulators of signal transduction and of cytokines in the hepatic microenvironment, which may contribute to a hyporesponsive state in liver DC. Analysis of signaling molecule expression within DC in liver transplant tissue is likely to uncover its relation to allograft outcome.

摘要

对肝脏间质树突状细胞 (DC) 的研究表明，这些重要抗原呈递细胞的成熟和功能可能会受到持续暴露于肠道微生物产物的抑制，特别是细菌脂多糖。新的证据表明，细胞内信号转导和细胞因子的特定调节剂在肝脏微环境中可能发挥作用，这有助于肝脏 DC 处于低反应状态。分析肝移植组织中 DC 内信号分子的表达可能揭示其与移植物结局的关系。