Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA.
Nat Rev Immunol. 2010 Nov;10(11):753-66. doi: 10.1038/nri2858.
The demands that are imposed on the liver as a result of its function as a metabolic organ that extracts nutrients and clears gut-derived microbial products from the blood are met by a unique microanatomical and immunological environment. The inherent tolerogenicity of the liver and its role in the regulation of innate and adaptive immunity are mediated by parenchymal and non-parenchymal antigen-presenting cells (APCs), cell-autonomous molecular pathways and locally produced factors. Here, we review the central role of liver APCs in the regulation of hepatic immune function and also consider how recent insights may be applied in strategies to target liver tolerance for disease therapy.
肝脏作为代谢器官，从血液中提取营养物质并清除肠道来源的微生物产物，这一功能对其提出了要求，而肝脏独特的微解剖学和免疫学环境满足了这些要求。肝脏的固有耐受性及其在先天和适应性免疫调节中的作用是由实质细胞和非实质细胞抗原呈递细胞（APCs）、细胞自主分子途径和局部产生的因子介导的。在这里，我们综述了肝脏 APCs 在调节肝脏免疫功能中的核心作用，并考虑了如何将最近的研究进展应用于靶向肝脏耐受以进行疾病治疗的策略中。
