Mencoboni M, Lerza R, Bogliolo G, Flego G, Gasparini L, Pannacciulli I
Istituto Scientifico di Medicina Interna, Università di Genova, Italy.
In Vivo. 1990 May-Jun;4(3):171-3.
Several antiviral compounds showed a toxicity or hemopoietic progenitor cells, 2', 3' Dideoxycytidine (ddc) is the most potent drug in vitro against human T cell lymphotropic viruses and is now being tested on patients with AIDS and AIDS-related complex. We studied its toxicity on mouse hemopoietic progenitors. Results reported here show a toxic activity of ddc but further studies are required to ascertain whether this toxicity is of significance during clinical application.
几种抗病毒化合物对造血祖细胞表现出毒性，2'，3' - 双脱氧胞苷（ddc）是体外抗人类嗜T细胞病毒最有效的药物，目前正在对艾滋病患者和艾滋病相关综合征患者进行试验。我们研究了它对小鼠造血祖细胞的毒性。此处报告的结果显示了ddc的毒性活性，但还需要进一步研究以确定这种毒性在临床应用中是否具有重要意义。
