Ayaslioglu Ergin, Koçak Mukadder, Bozdogan Onder
Department of Infectious Diseases and Clinical Microbiology, Kirikkale University School of Medicine, Kirikkale, Turkey.
Am J Dermatopathol. 2009 Oct;31(7):687-90. doi: 10.1097/DAD.0b013e3181a5825e.
Human brucellosis is a multisystemic infectious disease with a broad spectrum of clinical manifestations. Severe complications involving musculoskeletal, nervous, genitourinary, and cardiovascular systems may be encountered during the course of the disease; however, cutaneous complications have been reported rarely. We report a patient with brucellosis in whom the main presenting clinical feature was a maculopapular rash and fever. He was initially diagnosed as brucellosis based on the standard tube agglutination test and blood culture positivity. Histopathologic examination of these maculopapular lesions showed perivascular and periadnexal inflammation with loose granuloma formation including giant cells. We emphasize that brucellosis is an infectious disease that should always be kept in mind in the differential diagnosis of a patient with rash and fever, especially in endemic areas.
人类布鲁氏菌病是一种具有广泛临床表现的多系统传染病。在疾病过程中可能会出现涉及肌肉骨骼、神经、泌尿生殖和心血管系统的严重并发症；然而，皮肤并发症的报道很少。我们报告了一名以斑丘疹和发热为主要临床表现的布鲁氏菌病患者。根据标准试管凝集试验和血培养阳性结果，他最初被诊断为布鲁氏菌病。这些斑丘疹病变的组织病理学检查显示血管周围和附件周围有炎症，并伴有包括巨细胞在内的疏松肉芽肿形成。我们强调，在皮疹和发热患者的鉴别诊断中，尤其是在流行地区，布鲁氏菌病是一种应始终牢记的传染病。
