Eruz Emine Dilek, Birengel Serhat, Azap Alpay, Bozkurt Gulden Yilmaz
Department of Clinical Microbiology and Infectious Diseases, Faculty of Medicine, Ankara University, 06100 Ankara, Turkey.
Case Rep Med. 2011;2011:614546. doi: 10.1155/2011/614546. Epub 2011 May 25.
Brucellosis is a zoonotic infectious disease, which mainly present with lymphoreticular system invovement. However any organ system can be attacked by the microorganism. In this paper we present a 52-year-old female patient who was admitted to the Infectious Diseases Department with complaints of fatigue, arthralgias, fever, and weight loss. In the medical examination and radiological analysis bilateral pleural effusions and hepatosplenomegaly were detected. Serum transaminase levels were two times higher than the upper limits of normal. Abdominal ultrasound revealed sludge in the gallbladder and multiple hypodense splenic lesions (the largest was 1 cm in diameter). Brucella melitensis was isolated from the blood culture of the patient. Rifampicin (600 mg/day) and doxycycline (200 mg/day) therapy was started. Follow-up chest radiography and ultrasonography revealed the absence of pleural effusion. Splenic lesions and hepatosplenomegaly were totally regressed. The patient has been followed for 3 months after 6 week antibiotic regimen without recurrence. Brucellosis was expected to be the cause of all pathological signs.
布鲁氏菌病是一种人畜共患传染病，主要表现为淋巴网状系统受累。然而，任何器官系统都可能受到该微生物的侵袭。本文介绍了一名52岁女性患者，因疲劳、关节痛、发热和体重减轻而入住传染病科。在体格检查和影像学分析中，发现双侧胸腔积液和肝脾肿大。血清转氨酶水平比正常上限高出两倍。腹部超声显示胆囊内有淤渣，脾脏有多个低密度病变（最大直径为1厘米）。从患者的血培养中分离出羊种布鲁氏菌。开始使用利福平（600毫克/天）和强力霉素（200毫克/天）进行治疗。随访胸部X线摄影和超声检查显示胸腔积液消失。脾脏病变和肝脾肿大完全消退。在6周抗生素治疗方案后，对患者进行了3个月的随访，无复发。布鲁氏菌病被认为是所有病理体征的病因。
