Curran J, Kolakofsky D
Department of Microbiology, University of Geneva Medical School, Switzerland.
Enzyme. 1990;44(1-4):244-9. doi: 10.1159/000468762.
The Sendai virus P gene contains overlapping open reading frames (ORFs), and several unusual mechanisms are used to produce multiple proteins from all three ORFs of this gene. These include the use of a non-AUG start codon, leaky ribosomal scanning, what appears to be scanning-independent ribosomal initiation and/or ribosomal jumping, and a form of mRNA editing.
仙台病毒P基因包含重叠开放阅读框(ORF),并且利用几种不同寻常的机制从该基因的所有三个ORF产生多种蛋白质。这些机制包括使用非AUG起始密码子、核糖体扫描渗漏、看似不依赖扫描的核糖体起始和/或核糖体跳跃,以及一种mRNA编辑形式。