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仙台病毒P/C信使核糖核酸上不同起始密码子处的核糖体起始作用

Ribosomal initiation at alternate AUGs on the Sendai virus P/C mRNA.

作者信息

Curran J A, Richardson C, Kolakofsky D

出版信息

J Virol. 1986 Feb;57(2):684-7. doi: 10.1128/JVI.57.2.684-687.1986.

DOI:10.1128/JVI.57.2.684-687.1986
PMID:3003399
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC252785/
Abstract

Peptide sera specific for the C, C/C', and P proteins of Sendai virus have been used to confirm that the viral nonstructural proteins originate from internal AUG codons and are translated in a different reading frame from that of the P protein. The C protein undergoes aberrant migration on sodium dodecyl sulfate-polyacrylamide gel electrophoresis and is expressed at higher levels in infected cells than are the P and C' proteins.

摘要

针对仙台病毒C、C/C'和P蛋白的肽血清已被用于证实病毒非结构蛋白源自内部AUG密码子，且以与P蛋白不同的阅读框进行翻译。C蛋白在十二烷基硫酸钠-聚丙烯酰胺凝胶电泳上出现异常迁移，并且在感染细胞中的表达水平高于P蛋白和C'蛋白。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/304b/252785/4bf4af4ca1fe/jvirol00113-0284-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/304b/252785/f67ce45a67eb/jvirol00113-0283-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/304b/252785/661ab43c5af3/jvirol00113-0284-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/304b/252785/4bf4af4ca1fe/jvirol00113-0284-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/304b/252785/f67ce45a67eb/jvirol00113-0283-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/304b/252785/661ab43c5af3/jvirol00113-0284-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/304b/252785/4bf4af4ca1fe/jvirol00113-0284-b.jpg

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