Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
Dig Dis Sci. 2010 Jun;55(6):1525-32. doi: 10.1007/s10620-009-0922-1. Epub 2009 Aug 11.
Studies investigating the association between interleukin10 (IL10) -592 promoter polymorphism and gastric cancer risk report conflicting results. The objective of this study was to quantitatively summarize the evidence for such a relationship.
Two investigators independently searched the MEDLINE and Embase databases. This meta-analysis included ten case-control studies, which included 1,715 gastric cancer cases and 2,783 controls.
The combined results based on all studies showed that there was no significant difference in genotype distribution (AA odds ratio [OR] = 0.88, 95% confidence interval [CI] = 0.66, 1.18; AC OR = 1.09, 95% CI = 0.95, 1.24; CC OR = 1.03, 95% CI = 0.89, 1.18) between gastric cancer and noncancer patients. When stratifying for race, the results were similar, except that patients with gastric cancer had a significantly lower frequency of AA (OR = 0.67, 95% CI = 0.52, 0.87) and a higher frequency of AC (OR = 1.34, 95% CI = 1.07, 1.68) than noncancer patients among Asians. When stratifying by the location of gastric cancer, we found that patients with cardia gastric cancer had a significantly lower frequency of AA (OR = 0.41, 95% CI = 0.20, 0.84) than those with noncardia gastric cancer among Caucasians. When stratifying by Lauren's classification of gastric cancer, we found that patients with diffuse gastric cancer had a significantly higher frequency of AA (OR = 1.91, 95% CI = 1.07, 3.41) than those with intestinal gastric cancer among Caucasians.
This meta-analysis suggests that the IL10 -592 promoter polymorphism may be associated with gastric cancer among Asians, and that differences in genotype distribution may be associated with the location and Lauren's classification of gastric cancer.
研究白细胞介素 10（IL10）-592 启动子多态性与胃癌风险之间关系的研究报告结果相互矛盾。本研究的目的是定量总结这种关系的证据。
两名调查人员独立检索 MEDLINE 和 Embase 数据库。本荟萃分析包括 10 项病例对照研究，共纳入 1715 例胃癌病例和 2783 例对照。
基于所有研究的综合结果显示，基因型分布无显著差异（AA 比值比 [OR] = 0.88，95%置信区间 [CI] = 0.66, 1.18；AC OR = 1.09，95% CI = 0.95, 1.24；CC OR = 1.03，95% CI = 0.89, 1.18）。按种族分层时，结果相似，但亚洲人群中胃癌患者 AA 基因型频率显著降低（OR = 0.67，95% CI = 0.52, 0.87），AC 基因型频率升高（OR = 1.34，95% CI = 1.07, 1.68）。按胃癌位置分层时，我们发现白种人中贲门胃癌患者 AA 基因型频率显著降低（OR = 0.41，95% CI = 0.20, 0.84）。按 Lauren 分类分层时，我们发现白种人中弥漫型胃癌患者 AA 基因型频率显著升高（OR = 1.91，95% CI = 1.07, 3.41）。
本荟萃分析表明，IL10-592 启动子多态性可能与亚洲人群的胃癌相关，基因型分布的差异可能与胃癌的位置和 Lauren 分类有关。
